Polyvinyl acetate or 'PVA glue' is often associated with school projects and woodworking. A key ingredient in a product may have hidden medical superpowers. Cancer A treatment based on research led by the University of Tokyo in Japan.
Especially compound polyvinyl alcohol to a Radiation therapy The compound used to treat head and neck cancer improves targeting of tumor cells while causing less damage to healthy ones.
"We got that. [polyvinyl alcohol]A compound called D-BPA used in the liquid resin greatly improves the effectiveness, which until now has been removed from the medicinal ingredients because it was of no use. He says. The senior author of the study is Takahiro Nomoto, a biomedical engineer at the University of Tokyo.

Cancer treatment Boron neutron capture therapy (BNCT) requires patients to take a drug that loads the tumor cells with the element BoronIn a radioactive explosion, it absorbs the supply of neutrons and decays, killing the surrounding cells.
While this precise targeting is effective, the low-energy neutron stream can only be deployed in cancers close to the skin's surface. How well boron is retained in tumor cells also affects its effectiveness.
By adding polyvinyl alcohol, the researchers had previously managed To improve the effectiveness of the important ingredient in the medicine called L-BPA.
However, L-BPA can enter healthy cells under certain conditions, which led the researchers to turn their attention to a similar substance called D-BPA.
Unlike L-BPA, D-BPA does not accumulate in cancer cells, which is why it has not previously been used in cancer treatment. Combined with polyvinyl alcohol, however, D-BPA was shown to be better than L-BPA in sequestering and retaining boron in tumors.
"In a subcutaneous tumor model, this system achieved highly tumor-selective concentrations that were unattainable by conventional approaches and resulted in severe BNCT effects." Write The researchers in their published article.
"[Polyvinyl alcohol] It can be a unique material to unlock the potential of seemingly inert molecules.
More research needs to be done to make sure this works Medical treatmentsBut lab tests are promising. If there is more boron in the cancer cells and it sticks around for a long time, the neutron streams should destroy the cancer cells faster, giving treatments that cause shorter damage.
"There is a lot of interest in developing drugs for cancer treatment and recent research and development has focused on complex, expensive molecules." He says. Nomoto.
"However, we were concerned that such methods would be very expensive when implemented, so that only certain patients would benefit. In this study, we aimed to develop a drug with a simple structure and high functionality at a low cost."
The study was published in Journal of controlled release.
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